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RE: [HAPS-L] End-product inhibition



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But isn’t this at a lower level of organization than the systems we usually refer to as “control systems”?  I would say end-product inhibition is negative feedback, but it isn’t an example of a “control system” because it is happening at the molecular rather than cellular level.

What do others think?

Margaret W.

 


From: HAPS-L-owner@xxxxxxxxxxx [mailto:HAPS-L-owner@xxxxxxxxxxx] On Behalf Of James S. Miller
Sent: Monday, February 12, 2007 9:19 AM
To: HAPS-L@xxxxxxxxxxx
Subject: Re: [HAPS-L] End-product inhibition

 

Biochemistry is full of metabolic pathways where the end product, or even sometimes intermediates, inhibits the first or second enzyme in the pathway.  This was always considered to be negative feedback in every text I've ever seen.  So, if I understand you correctly, the answer is yes.  It's a negative feedback homeostatic mechanism.

Harbut, Chester wrote:

On a recent essay exam I asked my students to give me an example of negative feedback.  Most used
parameters such as glucose concentration, temperature, even calcium concentrtion.  Two students however
used "end-product inhibition" of enzymes (with specific examples).  I''m just curious, do most of you
consider this negative feedback in the classical sense?